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For the earlier versions of our B 12 strips under the same preparation and operating conditions but without the spacer pad incorporation, the T/C ratio remained insensitive to the increase in the sample B 12 concentrations up until tens of nmol/L which demonstrates the significance of the spacer pad in the B 12 detection in the sub-nmol/L ranges

However, none of the currently used surgical methods could be considered an ideal surgical option that is effective, safe, and painless

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