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Patients should contact their healthcare provider if cold intolerance is accompanied by other signs of potential thyroid dysfunction, including severe fatigue that interferes with daily activities, unexplained weight gain despite continued medication use, significant hair thinning or loss, persistent constipation unresponsive to usual remedies, marked changes in skin texture (very dry or puffy skin), depression or cognitive changes, or muscle weakness and cramping

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These changes are gradual and usually track with the degree of weight loss and metabolic improvement, not the drug alone

The Smart Play: Abbott doesnt just want to sell one drug