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Slow metabolizers accumulate NAPQI longer, requiring stronger glutathione reserves
this difference may result from a ~5x stronger effect produced by GLP-1 analogs, compared to DPP-4 inhibitors (Charbonnel & Cariou, 2011) No change in weight Contraindications: type I diabetes (these patients lack pancreatic beta cells) diabetic ketoacidosis (it would not be effective for treating this condition) an association between DPP-4 inhibitors and heart failure has been observed for two members of this drug class in patients with type 2 DM and atherosclerosis
& Hwang, I
Estimated plasma half-life is approximately 2 hours, though precise human pharmacokinetic data remain limited and are largely extrapolated from animal and in vitro systems
