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Figure 5 4.1.2 Mechanistic insights The mTORC1/S6K1 pathway is one major mechanistic node linking chronically elevated circulating BCAAsarising from impaired catabolic clearanceto insulin resistance, operating in parallel with BCKA-mediated direct inhibition of Akt signaling and BCAC-driven mitochondrial dysfunction, as described in Section 2.2.1
[1] Peptide Therapeutics by J
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