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While oral supplements are commonly available, some brands also offer alternative forms such as liposomal or intravenous options, which may have different absorption rates and effectiveness
Finally, delineating tissue-preferential effects is essential to determine whether improvements in IR arise primarily from reduced hepatic lipid content or also involve amelioration of pancreatic steatosis and skeletal muscle lipid metabolism
Overall, these findings indicate that while HIIT alone effectively enhances body composition and physical function in obese older adults, the addition of CIT provides further benefits by promoting greater muscle strength and reducing fat mass, supporting HIIT-CIT as a promising combined strategy to improve metabolic and functional health in this population (33)
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