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The type, dosing and administration regimen of GLP-1RA have also been shown to influence adherence and persistence with treatment [26]
This property is directly related to its gastric origin: it resists enzymatic degradation in the stomach, which opens the door to oral administration a considerable advantage over other peptides that strictly require injection
We also allow the inputs to vary as functions of time (for example the amino acid input will vary because of meals) and compute the time course of each concentration and reaction rate
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