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Unapproved medicines obtained outside of licensed clinical trials carry significant safety risks, including unknown purity, incorrect dosing, and absence of medical supervision

The trials demonstrated that patients taking Wegovy with a reduced calorie meal plan and increased physical activity achieved a significant reduction in body weight compared with placebo (reduced calorie meal plan and increased physical activity only)

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Researchers introduced a ketone functional group into the erastin structure to obtain the carbonyl analog imidazole ketone erastin (IKE), which is more effective at inducing ferroptosis [128]