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Trends Food Sci Technol (2006) 17(9):50512.10.1016/j.tifs.2006.04.004 15 Fernandez-BolaosJHerediaAFelizonBBrenesMGuillenRRodriguezR

CMAJ: Canadian Medical Association journal = journal de lAssociation medicale canadienne 172 , 367379, (2005)

Several animals studies have found that GLP-1 agonists can reduce drug and alcohol seeking behavior, but there isnt strong data from human trials: one small trial found that GLP-1 agonists could reduce opioid cravings, for example, while another found they could reduce cravings for alcohol, but only in people who were living with obesity

These results suggest that GLP-1RAs inhibit bile acid synthesis through SREBP-2 suppression in PA-treated cells, possibly linked to reduced hepatic cholesterol levels following GLP-1RA treatment