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More than a quarter of people with Type 2 diabetes take GLP-1 receptor agonists, but the popular diabetes drugs might not work as well for people who have certain genetic variants, according to a new study by Stanford Medicine scientists and their collaborators

(10 pts) Oxidant Reductant RE(V) Succinate -CO a-ketoglutarate 2 -0.67 Acetate Acetaldehyde 2 0.60 Ferredokan (oxidized) Ferredoxin (reduced) 1 -043 2 H HE 2 042 NAD: NADH-H 2 -0.32 NADP NADPH-H 2 -0.32 Lipoate oxidured) Lipoate reduced 2 -0.29 Glutathione (oxidized) Glutathione (reduced) 2 03 EAD EADH 2022 Acetaldehyde Ethanol 2030 Pyruvate Lactate 2 019 Fumarate Succinate 003 Cytochrome (+3) Cytochrome (+2) 0.07 Dehydroascorbate Ascorbate 2 0.08 Ubiquinone (oxidured) Ubiquinone (reduced) 2 010 Cytochronne(+3) Cytochrome (2) 0.22 Fe(+3) Fe (-2) 0.77 02-27 HO 2 2 1

Key Takeaways Essential for Energy Critical for fatty acid metabolism Best Sources Red meat, poultry, fish, dairy Multiple Benefits Heart health, exercise, weight management Safe Usage Consult professionals before supplementing References Linus Pauling Institute, Oregon State University: L-Carnitine Highlights meat, poultry, fish, and dairy as the richest sources of L-carnitine

For psoriatic arthritis specifically, patients show improvements in both skin involvement and joint inflammation on GLP-1 therapy