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Standard commercial grade compounds containing unverified impurities yield skewed experimental results and non-reproducible trial outcomes

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SID is diagnosed in individuals without a prior history of T2DM, who meet standard diagnostic criteria for diabetes during glucocorticoid exposure ( The strongly diabetogenic effect of GCs is caused by increased insulin resistance, driven primarily by increased hepatic gluconeogenesis, lipolysis, and elevated circulating free fatty acids ( -cells and increase -cell glucagon production, collectively exacerbating hyperglycaemia ( Figure 1