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1 2 3 "Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders"
In AWARD-10 [31], a 24-week, randomized, double-blind, placebo-controlled trial evaluating once-weekly dulaglutide (administered at either 1.5 or 0.75 mg) as add-on therapy to SGLT2is in a total of 424 patients with inadequately controlled T2DM, only one episode of severe hypoglycemia was reported throughout the study, in a patient treated with dulaglutide 0.75 mg, confirming the very low incidence of serious hypoglycemia with GLP-1RAs in combination with SGLT2is [31]
Conclusions In general, our study indicated that chronic ethanol exposure may cause exacerbated continuously deteriorating cognitive impairment and neuroinflammatory damage in APP/PS1 mice compared to WT mice
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