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Safety in TRIUMPH-1 The safety profile was consistent with incretin-class therapies: Most common AEs (12 mg dose): - Nausea: 42.4% - Diarrhea: 32.0% - Constipation: 26.1% - Vomiting: 25.3% Dysesthesia (a sensory disturbance tingling, numbness) and urinary tract infections were reported in approximately 10% of patients on the highest doses, but were generally mild to moderate and mostly resolved during treatment

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*Methylcobalamin (Vitamin B12) is also indicated in those with pernicious anemia, diabetes, neuropathy, heart disease, circadian rhythm sleep disorders, memory loss, depression, fatigue, AIDS, inflammatory bowel disease (IBD), Lyme disease, osteoporosis, tendonitis, psychiatric disorders, Alzheimers disease, liver and kidney disease, and asthma