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When looking at the whole patient and potential comorbidities, treatment with GLP-1s may be strongly beneficial for the overall health of many people with substance use challenges, both because of direct benefits as well as the potential to reduce the number of medications that patients require

Sulfonylurea drugs affect sulfonylurea receptor 1 (SUR 1), which leads to the closure of adenosine triphosphate (ATP)-dependent potassium channels, preventing potassium from leaving the cell and depolarizing the cell membrane, leading to an influx of calcium and triggering insulin release

However, not all medications automatically disqualify you

Clean the chosen site with an alcohol swab and allow it to dry completely