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Furthermore, cytoplasmic dsDNA levels are significantly increased in FLS from RA patients, causing upregulation of genes such as IL-6 , CXCL10 , TNF- , MMP-13 , IL-1 , and IL-8 via a cGAS-dependent mechanism that also disrupts joint homeostasis [22]
PMID: 31 NauckMAQuastDRWefersJPfeifferAFH
Little work has previously been undertaken to evaluate safety with long-term efficacy and cardio-renal benefits of such therapies
Tang LJ, Luo XJ, Tu H, Chen H, Xiong XM, Li NS, et al
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