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Less body weight means less compressive load on the knee with every step Adipose tissue produces inflammatory signalling molecules (IL-6 and TNF-alpha) that drive joint pain, and reducing fat tissue reduces those signals 3 The IDEA trial in 2013 demonstrated clinically meaningful reductions in pain through diet and exercise alone, without any GLP-1 medication 3 Whether semaglutide also has anti-inflammatory effects independent of weight loss, through GLP-1 receptors on immune cells, is a separate question
Of all the nutrients, protein deserves particular attention
Aberrant B cell expansion and survival contribute to B cell malignancies, such as multiple myeloma, diffuse large B cell lymphoma, and chronic lymphocytic leukemia, which are frequently associated with TRAF3 gene deletions or inactivating mutations (114116)
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