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Expect modest weight loss of around 2% (3 to 5 pounds), gradual appetite changes, and some adjustment as your body gets used to the medication
This phenomenon is associated with uncoupled mitochondrial respiration, elevated proton leak, ROS formation, cellular apoptosis, and, more important, increased myocardial oxygen consumption (56)
Coffee has also been linked to increased stomach acid, which could impact how an oral GLP-1 is absorbed
None of this means the compound is ready for people, because it is still being tested in trials
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