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Glutathione is an important and potent antioxidant for the human body
Independent predictors of amputation identified in the study included prior amputations, male sex, non-Asian ethnicity, history of PAD, history of neuropathy, albuminuria, and elevated HbA1c levels at baseline.38 While this finding was not replicated in other randomized clinical trials on SGLT-2 inhibitors, it is recommended to conduct a thorough screening for risk factors for amputations when initiating SGLT2 inhibitors
However, until very recently, these agents were only available as s.c injections, which may not be the most desirable mode of delivery for some patients [90]
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