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Nevertheless, IGF-1 gene transfer to CCl 4 rats to overexpress intrahepatic IGF-1 relieved hepatocyte oxidative stress and premature senescence, which was likely mediated by the p53/progerin pathway, to improve hepatic steatosis and fibrogenesis
Michael Perelman introduced the concept of the sexual tipping point, which looks at the interaction of excitatory and inhibitory biomedical, psychological, and cultural factors to determine sexual response
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