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In marked contrast to the pGSH1-GAP1 strain, the control strain showed a decrease in GSH level when cultured with D-HIS (Fig

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Since these metabolic reactions occur mainly in the liver, impairment in this pathway could lead to the accumulation of excess metabolites, including byproducts of amino acid and lipid metabolism, in the liver and thereby contribute to the pathogenesis of Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) 12,13