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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025

Lancet 397 , 22842303 (2021)

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Your body shape will not be defined yet , but early changes may start to appear as inflammation subsides