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By regulating the activity of the PPP and the levels of R5P, NRF2 may influence the production of both purines and pyrimidines
We exposed cell lines that had either Keap1, Nrf2 or Srxn1 tagged with green fluorescent protein (GFP) to a concentration range of DEM and monitored the response of these Nrf2 pathway components using high throughput confocal imaging (Fig
Agonists and inhibitors of ferroptosis Ferroptosis presents a promising avenue for therapeutic intervention, and beyond the realm of genetic regulators, the identification of various small molecules associated with ferroptosis has opened up new possibilities
PubMed World Health Organization
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