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We should re-examine eligibility frameworks for GLP-1 therapies, she said
Prescribing Information: Contrave (naltrexone HCl and bupropion HCl extendedrelease)
1979 Mar;163(2):195205
FDA staff's own briefing document, posted publicly ahead of the meeting as part of the docket, proposes that TB-500 (free base) and TB-500 acetate not be added to the list, citing incomplete physicochemical characterization, a lack of evidence of effectiveness for wound healing (including an in-vitro fibroblast study in which TB-500 reportedly did not induce wound healing), and insufficient nonclinical and clinical safety data
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