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3.3.4 Polyethylene glycol loxenatide The early GLP-1R agonist has many defects, such as multiple injections and a high incidence of adverse reactions in the digestive tract, which limits its clinical application
The more clinically relevant question is whether controlled glucagon receptor activation, when paired with GLP-1 and/or GIP receptor agonism, can shift glucagons metabolic impact from primarily hyperglycemic toward thermogenic, lipolytic, and hepatometabolic benefit
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