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Dipeptidyl peptidase-4 inhibitors, pancreatic cancer and acute pancreatitis: a meta-analysis with trial sequential analysis

While mechanisms remain speculative, one possible explanation is that such hair loss is down to rapid weight loss and its associated metabolic changes and nutritional deficiencies rather than the medications themselves

doi: 10.1007/s11845-020-02441-x 140 JiaMTanXYuanZZhuWYanP

One of these classes (class I ferroptosis-inducing compounds, erastin derivatives) inhibits GPX4 through the depletion of glutathione, and the other (class II ferroptosis-inducing compounds, RSL3 derivatives) inhibits GPX4 directly, without glutathione depletion