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Yes, with a clear dose-response relationship: 0.25 mg dose: 9-11% constipation rate 0.5 mg dose: 12-14% constipation rate 1.0 mg dose: 15-18% constipation rate 2.4 mg dose: 23-24% constipation rate The increase from 0.5 mg to 2.4 mg roughly doubles the constipation risk
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For instance, those with GI disease, a history of gallbladder disease, a high risk for pancreatitis, or kidney and liver issues would likely be advised not to take retatrutide
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