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The altered gastric emptying and potential changes in food intake associated with semaglutide therapy may affect the absorption and metabolism of warfarin, potentially leading to fluctuations in international normalized ratio values
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While glucagon increases blood glucose levels via stimulating the liver to release glucose, glucagon-like peptide-1 (GLP-1) has pretty much the opposite effect in that it can decrease blood glucose by stimulating more insulin to be released by the beta-cells in the pancreas.[ref] GIP (glucose-dependent insulinotropic peptide) not only acts on the GIP receptor (GIPR) in the pancreas, but it also acts upon other tissues such as fat, bone, and endothelial cells lining blood vessels
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