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Mozaffarian D, Agarwal M, Aggarwal M, et al

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In the present study, it was found that Doxorubicin and Cyclophosphamide significantly hindered BDNF and p-CREB expression in both brain regions of chemobrain-induced rats while L-carnitine reversed these actions by decreasing p65 NF-B nuclear translocation and significantly increasing the expression of BDNF and p-CREB