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Future clinical trials evaluating IL-4R inhibitors in OvCa could provide critical insights into their efficacy in reversing macrophage-mediated immunosuppression and enhancing response rates to immune checkpoint inhibitors (72)

Front Pharmacol 9:1325 Ye D, Li M, Zhang Y, Wang X, Liu H, Wu W (2017) Cryptotanshinone regulates androgen synthesis through the erk/C-fos/cyp17 pathway in porcine granulosa cells

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1, 2 They often develop in childhood (juvenile lentigo) and become more conspicuous during pregnancy