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As demand collides with coverage constraints, a growing out-of-pocket/cash-pay segment is emerging, where consumers effectively treat weight-loss pharmacotherapy as a discretionary wellness purchase: manufacturers and intermediaries are explicitly building self-pay pathways (e.g., LillyDirects self-pay programme

Further research is required at the genetic, epigenetic, proteomic, and metabolic levels to identify potential targets for CSCs, helping to develop new therapies that are more effective to the existing challenge of cancer drug resistance [328]

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