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Cross-compound receptor-occupancy percentages are deliberately not compared here: occupancy (pRO) is a modeled inference, not a measurement, and Willard 2020 cautions that "calculating pRO values has caveats." These EC50s measure functional potency, not binding affinity
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Clinical data demonstrates that gastrointestinal side effects follow a predictable pattern of being most prominent during treatment initiation and dose escalation periods, then declining substantially as the body adapts
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