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Discussion SURPASS-6 showed that, in comparison with basal-bolus insulin therapy, treatment with tirzepatide as an add on to basal insulin in adults with long-standing T2D provided superior and clinically meaningful glycaemic control and had the additional benefits of reducing body weight and being associated with substantially less hypoglycaemia and insulin use [39]
This paper provides genetic evidence of AMPK-dependent effects of metformin on lipogenesis inhibition and fatty acid oxidation stimulation
Residual OCTN2 transporter activity, carnitine levels and symptoms correlate in patients with primary carnitine deficiency
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