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The early cancer therapies referred to antimetabolites, such as methotrexate (a folate analog) and 5-FU (a pyrimidine analog), that competitively inhibit key metabolic enzymes (e.g., dihydrofolate reductase and thymidylate synthase) in in vivo , thereby affecting or antagonizing cancer cell metabolism and proliferation (Lukey et al., 2017)
Harnessing the power of glutathione for melanin regulation means moving past superficial topical cosmetics and targeting hyperpigmentation directly at its intracellular source
However, it should be used under medical supervision
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