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Possible idiopathic intracranial hypertension, which has been reported rarely with GLP-1 agonists

It reversed glucose dysregulation without detrimental effects on metabolically healthy animals and reduced body weight, lowered fasting blood glucose, decreased glycosylated hemoglobin (HbA1C), improved glucose tolerance, and protected pancreatic islet architecture in diabetic fatty Zucker rats 22,23,24

If tirzepatide has been exposed to temperatures above 86F (30C) or left unrefrigerated beyond 21 days, immediate action is necessary to ensure continued safe and effective diabetes or weight management

Real-world data tells a more nuanced story Clinical trials represent controlled environments with specific populations