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GLUT4, which is primarily located in striated muscle (skeletal and cardiac) and adipose tissue, plays a major role in regulating glucose uptake and overall energy balance
B12 is primarily found in animal-based foods such as meat, dairy, and eggs, and is absorbed in the small intestine after binding to a protein
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[3][16][17] In conditions such as obesity, type 2 diabetes, and aging, NNMT is overexpressed in adipose tissue and skeletal muscle, where it depletes cellular pools of NAD+ and SAM
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