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Introducing retatrutide Retatrutide, also known as LY3437943, is a novel triple-hormone receptor agonist that targets the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors

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Additionally, glucagon has been shown to have anti-apoptotic effects on hepatocytes stimulated by Fas ligand activation and different experimental models of hepatotoxicity, and GCGR knockout results in increased hepatic susceptibility to apoptotic injury