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doi:10.1056/NEJMoa2500969 2
Semaglutide helps to regulate your appetite by making you feel fuller for longer after eating
The protocol: Reduce sulfonylurea dose by 50% when starting semaglutide Monitor blood glucose before meals and at bedtime for 2 weeks Many patients discontinue sulfonylureas entirely within 4 to 8 weeks as semaglutide reaches therapeutic levels The SUSTAIN-2 trial (Ahrn et al., Diabetes Care , 2018) showed that 41% of patients on sulfonylureas plus semaglutide experienced hypoglycemia, compared to 11% on semaglutide alone
Switch to a different anatomical zone and let the affected area rest for at least four weeks
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