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A major player in this process is PC, an anaplerotic enzyme that enables the beta cells to convert half of glucose-derived pyruvate into metabolites that participate in shuttles or cycles that provide intracellular messengers including NADPH, GTP, precursors of short-chain acyl-CoAs, lipids and amino acids which support K ATP -independent insulin secretion that may be equal in importance to ATP production by mitochondria for insulin secretion