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GLP-1RAs also promote endothelial barrier integrity via activating protein kinase A (PKA)- and Ras-related C3 botulinum toxin substrate 1 (Rac1) [106]
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Circulating Tumor DNA (ctDNA) for Surveillance Liquid biopsy technologies to detect ctDNA from NF1-deficient or TP53-mutant clones are being developed for monitoring disease recurrence or transformation in high-risk NF1 patients
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