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In many cases, this has been due to issues with study design, such as: small sample sizes short follow-up durations differences in PRP preparation, administration, and dosages between studies large differences in the time between individual PRP treatments between studies inclusion of data from studies other than randomized controlled trials (RCTs) potential experimenter bias, or lack of blinding However, researchers continue to study PRPs effectiveness using high quality, large-scale RCTs

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