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Indeed, when mice lacking GLP-1 receptors in the CNS were given the GLP-1-estradiol analogue, weight loss was equivalent only to that of GLP-1 administered peripherally

Talk with your healthcare provider before starting any new medicine, including over-the-counter, natural products, or vitamins

The recommendation is to discontinue before planning a pregnancy

Patients with a history of pancreatitis or gallbladder disease also warrant careful monitoring, as GLP-1 medications have been associated with gallstones and gallbladder inflammation in some cases