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In STZ-treated animal groups, two distinct zones were identified based on glial protein staining intensity: 1) the immediate ventricular border area (area of replacement gliosis), and 2) the adjacent hypothalamic nuclei region with moderate changes, where measurements were performed
A study has shown that lixisenatide inhibits inflammation of RA in human FLSs by downregulating IL-6, IL-8 and TNF-, while also inhibiting cellular communication pathways including c-Jun N-terminal kinase (JNK) and NF-B [239]
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