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NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues

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Type 2 Diabetes Models: Phase 3 TRANSCEND-T2D-1 data demonstrated HbA1c reductions of 1.7-2.0% and mean weight loss of 36.6 lbs over 40 weeks