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Whilst some blood glucose improvements may appear within the first week, the medication reaches steady-state concentrations after 4 to 5 weeks, with maximal glycaemic effects typically observed over 3 to 6 months following dose titration

J Toxicol Clin Toxicol 1999;37:73151

When these toxins leak into the bloodstream, they can cause a systemic attack on the body caused by your own immune system, as it becomes unable to properly differentiate toxins and its own cells