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While some men notice improvements in libido, energy, and mood within a few weeks of starting TRT, changes in muscle mass, strength, and body composition typically develop gradually over several months

Judge Robert Kirsch wrote that "clinical trials are complicated and nuanced, and investor calls are not scientific conferences." Get the market news that matters in a five-minute read with Market Briefs, our free daily newsletter Investors argue that Novo Nordisk's earlier communications glossed over this design feature, creating an expectation that nearly all participants would reach the highest dose and thus achieve maximum weight loss

Do not try to force them to wake up, as this may increase their distress

The safety data, while reassuring, comes primarily from shorter-duration studies