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Table 7) (see Supplementary Material for Clinical Takeaways)
Caution is advised for patients with a history of pancreatitis, gallbladder disease, kidney disease, diabetic retinopathy, or gastrointestinal motility disorders
These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form
These are critical factors for reproducible data
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