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After conversion to its active metabolite MPP, it selectively enters dopaminergic neurons via the dopamine transporter and blocks mitochondrial complex I, causing increased superoxide production, impaired oxidative phosphorylation (OxPhos) and ATP generation, and eventual dopaminergic neuronal death [12,13,14]

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The authors noted BPC-157 reduces the duration of immobility to a greater extent than imipramine in their experiments

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