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Free Radic Biol Med 18:321336 Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage
Reported side effects are usually mild and may include gastrointestinal symptoms such as bloating, cramping, or loose stools
Structurally it is nicotinamide mononucleotide joined to adenosine monophosphate through a pyrophosphate bridge, and its redox chemistry is confined to the nicotinamide ring: reduction is a stereospecific two-electron hydride transfer to C4 giving NADH, with a standard reduction potential near -0.32 V at pH 7
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