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But the specific protocols differ in meaningful ways
The active pharmaceutical ingredient (API) for compounded semaglutide comes from FDA-registered API manufacturers
In SURPASS-2, where tirzepatide was compared with semaglutide 1 mg in adults on metformin, the 15 mg dose showed a 2.3 percentage point reduction in A1c and an 11.2 kg reduction in body weight at 40 weeks
Regular follow-up ensures tolerance, efficacy, and early detection of adverse events
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