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The results showed that 4-OI significantly inhibited Erastin-induced BMSCs ferroptosis by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, reduced reactive oxygen species levels and oxidative damage, and restored antioxidant capacity
Gokhale A, Hartwig C, Freeman AA, Bassell JL, Zlatic SA, Savas CS, et al
Cartilage protection follows suitless oxidative stress means diminished matrix metalloproteinase activity, halting erosion
R.VinceV.WilliamsN
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