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Diabetologia 49 , 452458 (2006)
Muscle mass decreases by about 3% to 8% per decade after age 30, and this loss accelerates after 50
Freeze-thaw sensitivity is lower than for a peptide, since there is no secondary structure to lose, but aliquoting still avoids repeated stopper punctures and concentration drift from evaporation
Whilst the market is currently led by Novo Nordisks semaglutide (Ozempic/Wegovy) and Eli Lillys tirzepatide (Mounjaro/Zepbound), stronger competition is expected with new entrants (Boehringer Ingelheim, Amgen, Pfizer, Roche amongst others) offering novel mechanisms (dual agonists, triple agonists and amylins), formulations (oral vs injectable) and dosing regimens (daily vs weekly vs monthly).
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